The scientific mechanism and influence of membrane separation technology on the fine separation of blood components

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In the blood concentration process, membrane separation technology realizes fine stratification and efficient concentration of blood components through its unique selective permeation characteristics. Ultrafiltration membranes, such as PES membranes, are designed to allow smaller molecular weight plasma components to pass through while blocking larger particle size blood cells. The selectivity and separation ability of this membrane material mainly depend on its pore size, shape and surface properties.


The experimental data show that the ultrafiltration membrane with appropriate molecular weight retention can effectively remove the water in plasma and achieve the concentration of plasma proteins and other bioactive substances under the premise of ensuring that the blood components are not damaged by high temperature. For example, for plasma proteins such as immunoglobulin G (IgG), fibrinogen, and various coagulation factors, these macromolecules can be selectively retained and concentrated through membranes under appropriate operating conditions.


In addition, the membrane separation process is carried out at room temperature, avoiding the problem of protein denaturation that can be caused by traditional heat treatment methods, which is essential for maintaining the physiological function of heat-sensitive bioactive ingredients such as interleukins and growth factors. At the same time, because the membrane separation process is a physical separation method, it can also achieve a better removal effect for possible pathogens, such as viruses, bacteria, etc., so as to significantly improve the safety and effectiveness of blood products.

Further research has also revealed the potential of membrane separation technology in the separation efficiency of blood components, through the optimization of membrane material properties and the development of new membranes, it is expected to achieve higher accuracy of blood component separation in the future, and adapt to the individual needs of different blood product production. In general, the application of membrane separation technology in the blood concentration process has brought revolutionary changes to the modern blood products industry, and has promoted the advancement of the technical level and product quality standards of the entire industry.

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